Raised serum transaminases: not always liver disease

Paracetamol poisoning resulting in massively raised serum transaminases.

Sir, Paracetamol poisoning is not a very frequently encountered problem in ouur population, as compared to the incidence in the west. Paracetamol (acetaminophen) is being used as an effective and safer analgesic as compared to non-steroidal anti inflammatory drugs, when administered in therapeutic dose. In contrast to aspirin, it is more likely to cause hepatotoxicity, when taken in larger than...

All that glitters is not gold: elevated liver enzymes do not mean liver disease always.

Raised serum transaminases during treatment with pegylated interferon for chronic hepatitis C

Introduction: Serum transaminases rose significantly in 7 patients with chronic hepatitis C, genotypes 2 and 3, who were treated with pegylated interferon and ribavirin. Methods: 219 patients with chronic hepatitis C, genotypes 2 and 3, were treated between 2005 and 2011 following the same protocol. For the 7 patients presented in this paper, the initial liver screen revealed chronic hepatitis ...

Review of pyridoxal phosphate and the transaminases in liver disease.

In vitro supplementation with the active form of vitamin B6, pyridoxal-phosphate (PLP), increases measurements of both serum aminotransferase enzymes, L-aspartate: 2-oxoglutarate amino transferase, EC 2.6.1.1 (AST) and L-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2 (ALT). The plasma PLP level in normal individuals clearly relates inversely to the degree of stimulation of serum AST and A...

Late-onset Pompe Disease with Elevated Liver Transaminases: A Case Report

Pompe disease or type II glycogen storage disease is a rare autosomal hereditary disease. The prevalence of the disease is about 1 in 40,000 to 1 in 300,000 population. It usually occurs as a result of glycogen accretion following acid maltase deficiency. The current treatment is enzyme replacement therapy, which may slow down the disease progression. Sometimes, the clinical presentation can be...